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Breakthrough Bio
ACCELERATORS > OUR ACCELERATORS > BREAKTHROUGH BIO
BREAKTHROUGH BIO
Connecting biotech and medtech startups from Israel and Taiwan with U.S. investors, regulators, mentors, and industry partners.
ACCELERATORS > OUR ACCELERATORS > BREAKTHROUGH BIO
BREAKTHROUGH BIO
Connecting biotech and medtech startups from Israel and Taiwan with U.S. investors, regulators, mentors, and industry partners.
Innovation in biotech and medtech has gone global, with groundbreaking science emerging from academic labs, corporate spinouts, and founder-led startups around the world. What has not kept pace is access, and the path to market is still not open to everyone. Breakthrough Bio exists to close that gap, giving high-potential startups a direct, guided path into one of the most critical expansion markets for their growth. The program goes beyond exposure, giving the best companies from these ecosystems the one-to-one support, regulatory guidance, investor relationships, and industry connections that accelerate commercialization, so their innovations reach patients here and in their home countries.
THE GOAL: COMMERCIALIZATION
Breakthrough Bio provides a highly personalized commercialization experience tailored to each company's stage, technology, and growth objectives.
MARKET ENTRY
Build in months the positioning, relationships, and know-how that normally take years, guided by people who have done it.
DECISION MAKER ACCESS
Curated engagement with U.S. investors, pharmaceutical and healthcare leaders, regulatory experts, and business development partners.
FLAGSHIP CONFERENCE ACTIVATION
Preparation to convert LSI USA and BIO International into relationships and deals, plus a network that keeps working after the finale.
WHO SHOULD APPLY?
Breakthrough Bio backs biotech and medtech companies headquartered in Israel or Taiwan.
PHARMACEUTICAL (BIOTECH)
Therapeutic development spanning small molecules, biologics, cell therapy, and gene therapy
MEDICAL DEVICES (MEDTECH)
Medical devices, diagnostics, imaging, surgical devices, wearables, implantables, and connected devices.
AI DRUG DISCOVERY (TAIWAN ONLY)
Platforms applying AI/ML to target identification, hit generation, lead optimization, or clinical trial design.
FIND YOUR PROGRAM
Select your country cohort for eligibility, application details, and key dates.
For questions about our programs, contact our team directly at programs@masschallenge.org.
Now Accepting Applications
Open Program
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Open Program
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Open Program
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Founder stories and alumni spotlights coming soon!
Featuring real-world outcomes, pilots, partnerships, and breakthroughs from the global MassChallenge network.
REAL VOICES. REAL IMPACT.
MassChallenge has been incredible for us. It’s hard to be an entrepreneur, especially in climate, and the programming helped us see that we’re not the only ones in this. One of the main learnings I’ve gotten from this program is that impact and profitability are not mutually exclusive.
DAVID GORY
Founder and CEO at Airbuild
I wouldn’t just say this was something that I needed professionally, but on a personal level too. It’s about you as a person first. The people at MassChallenge and this community made me feel confident stepping into healthcare in a way I wasn’t before.
KYLE HENRY
CEO and Co-Founder, Tune Health
MassChallenge has been an incredible opportunity for us. It’s rare for a startup at our stage to work directly with enterprise partners. Through the program, we’ve been able to engage with enterprise users early on, understand their pain points, and build better solutions. Over the past few months, we’ve taken our product from prototype to production-ready, and without MassChallenge, this progress wouldn’t have been possible.
SHUAI LI
2x Founder
It takes a community to raise a startup. You can be deep in technology, but you need the network, the right advisors, and the right connections. That’s what MassChallenge brought, and it made something complex feel executable.
RICK WHITTAKER
CEO and CoFounder of AirShare
I am so excited for the networking we’ve gone through. Together it takes all of us to make the world a better place. If you’re looking for the networking and the connections and the people that will help you take your company to the next level, this is one of the most worthwhile programs.
JIM BOYTE
Founder & CEO at ActiveDefender
FEATURED PARTNERS
FAQs
The program itself carries no participation fee. Selected companies are responsible for covering their own U.S. visit costs, including travel, lodging, meals, and any professional services required, for each of the three in-person immersions. Selected companies will need to show proof of flights and hotels in advance of the January Kickoff.
Yes, consistent founder and/or senior executive participation is required. At least one founder or senior executive must commit to attending all three in-person visits in 2027: Boston in January, San Diego in March, and Philadelphia in June.
Not for the inaugural cohorts. The Israel cohort is open only to companies incorporated and operating in Israel; the Taiwan cohort is open only to companies headquartered in Taiwan.
Israel and Taiwan are the program’s inaugural partners. Additional countries have not been confirmed yet. Government and innovation agencies interested in participating in the 2027-28 Breakthrough Bio program can contact our team at partnerships@masschallenge.org.